#FuckCancer: 60 Minutes

60MinutesKillingCancer

Last night, the American TV newsmagazine, 60 Minutes, aired a remarkable two-part report about a Phase I trial at Duke University. They’ve developed a modified polio virus that has seen some success in treating glioblastoma, an aggressive brain cancer.

In the lab, this oncolytic virus has also worked against lung, pancreatic, colorectal, and other solid-mass malignancies.

The video is available at this page. If the video is geo-restricted, just scroll down to read the illustrated transcript. There’s also the producer’s notebook at this page.

Interestingly, this was also reported by ABC News back in 2013. These reports tend to pass by people until it becomes personal.

Additional:

Targeting Cancer with Genetically Engineered Poliovirus (PVS-RIPO)

Previously here:

#FuckCancer

4 Comments

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4 responses to “#FuckCancer: 60 Minutes

  1. E.T.

    Cancer immunotherapy is a new approach where the first drugs were approved, starting with advanced melanoma (see, e.g., http://www.nytimes.com/2014/06/03/business/cancer-researchers-report-longer-survival-rates-with-immunotherapy.html) and advancing to other tumor types.
    The main idea is to block the paths by which the tumor is hiding from the immune system and let the immune system unleash its wrath at the aberrant cells. These things take time but I think it has enormous potential.
    I hope other approaches (such as the viral vehicle) will be successful as well. The more tools the oncologists have the more patients they will be able to treat.

  2. Ric Day

    The really interesting thing about this “new” (3+ years old) approach at Duke is, they have found a way to use a modified virus to trigger an immune response in the brain, getting past the blood-brain barrier, and it seems to be working well now that they have got the dose size sorted out.

    GBM is quite uncommon (2 or 3 cases per 100,000 adults in North America and Europe, mostly among an older, male cohort) and almost always leads to a quite quick death.

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